Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles
نویسندگان
چکیده
منابع مشابه
Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles.
The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates intracellular levels of PIP3 and antagonizes the PI3K signaling pathway important for cell survival. The present study determined whether altered distribution of PTEN occurs in Alzheimer's disease (AD) brains. We investigated a possible role for PTEN in postmortem brain tissues from elderly controls and pa...
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Three monoclonal antibodies to neurofilaments (RT97, BF10 and 147), two of which also recognised neurofibrillary tangles (RT97 and BF10), have all been shown to be specific for phosphorylated epitopes. Treatment of histological sections with alkaline phosphatase prior to immunostaining resulted in reduction of axonal neurofilament staining with all three whilst the neurofibrillary tangles stain...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2010
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2009.12.078